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Studies on Organophosphorus Compounds 91: A Novel Synthesis of 1-Hydrazinoalkylphosphonic Acids and Derivatives Thereof
31 December 2000 (online)
Condensation of diethyl phosphite with aldehydes followed by subsequent sulfonylation of the resulting hydroxy group formed with mesyl chloride gave the corresponding 1-sulfonyloxyalkylphosphonates, which led to the convenient synthesis of 1-hydrazinoalkylphosphonates via nucleophilic substitution by hydrazine. The products could be converted to the corresponding 1-hydrazinoalkylphosphonic acids by acid hydrolysis in high yield.
nucleophilic substitution - 1-mesylalkylphosphonic acids - hydrazine