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Synlett 1995; 1995(SI): 575-577
DOI: 10.1055/s-1995-5268
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A Convenient Synthesis of Versatile Side-chain Intermediates for Carbapenem Antibiotics

Isao Kawamoto* , Rokuro Endo, Katsuya Ishikawa, Katsuhiko Kojima, Masao Miyauchi, Eiji Nakayama
  • *Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Toyko 140, Japan
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Publication Date:
31 December 2000 (online)

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A useful synthesis of (2S, 4S)-4-(4-methoxybenzylthio)-1-substituted pyrrolidinecarboxylic acid is reported. At each step, practically all compounds were obtained in crystalline form by simple procedure without column chromatography. These compounds are versatile side-chain precursors to carbapenem antibiotics.

substituted pyrrolidinecarboxylic acid - N-methylation - side-chain precursors of carbapenem - β-lactam antibiotics

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