Download PDF
Synlett 1995; 1995(SI): 510-512
DOI: 10.1055/s-1995-5263
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Design and Synthesis of D-Ribofuranoamidrazones as Inhibitors of Nucleoside Processing Enzymes

Markus Boutellier, Bruce Ganem* , Benjamin A. Horenstein, Vern L. Schramm
  • *Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, USA
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The five-membered amidrazones 1-4, designed as stable mimics of the ribofuranosyl cation, are potent competitive inhibitors of nucleoside hydrolase from Crithidia fasciculata.

nucleoside hydrolase - transition structure - thionolactam addition

      >