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Synlett 1995; 1995(11): 1143-1144
DOI: 10.1055/s-1995-5215
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Synthesis of Highly Functionalized Thiophenes. 4-Aryl-3-carboxylate Derivatives

Gary M. Coppola, Robert E. Damon* , Harvey Yu
  • *Department of Atherosclerosis and Vascular Biology, Preclinical Research, Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, Route 10, East Hanover, N.J. 07936
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Publication Date:
31 December 2000 (online)

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A general method for the preparation of aromatic α-mercapto ketones 10 has been developed. These substrates react with vinyl phosphonate 11 to form highly functionalized thiophenes.

4-arylthiophenes - Michael addition - intramolecular Wittig reaction - α-mercapto ketones - aromatization