Synlett 1995; 1995(10): 1017-1020
DOI: 10.1055/s-1995-5164
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Solid Phase Synthesis of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination

Steven V. Ley* , Donna M. Mynett, Wim-Jan Koot
  • *Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Tandem Michael addition reactions of polymer bound acrylates with cyclohexenones and subsequent reductive amination was achieved, which after cleavage from the support under reductive, acidolytic or aminolytic conditions afforded a wide variety of bicyclo[2.2.2]octanes. The process may find application in combinatorial library synthesis.