Download PDF
Synlett 1995; 1995(10): 1017-1020
DOI: 10.1055/s-1995-5164
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Solid Phase Synthesis of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination

Steven V. Ley* , Donna M. Mynett, Wim-Jan Koot
  • *Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Tandem Michael addition reactions of polymer bound acrylates with cyclohexenones and subsequent reductive amination was achieved, which after cleavage from the support under reductive, acidolytic or aminolytic conditions afforded a wide variety of bicyclo[2.2.2]octanes. The process may find application in combinatorial library synthesis.

Solid Phase Synthesis - Tandem Michael Addition - Reductive Amination