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Synlett 1995; 1995(9): 961-962
DOI: 10.1055/s-1995-5151
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Highly Diastereoselective Addition of Organometallic Reagents to Chiral Imines Derived from 1-(2-Methoxyphenyl)ethylamine

Yukihiko Hashimoto* , Natsuko Kobayashi, Akiyoshi Kai, Kazuhiko Saigo1
  • *Department of Chemistry and Biotechnology, Graduate School of Engineering, the University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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The chiral imines prepared from an artificial chiral auxiliary, 1-(2-methoxyphenyl)ethylamine, and various aldehydes, reacted with organolithium reagents to give the corresponding chiral amines with high diastereoselectivity.

1-Phenylethylamine - Imine - Chiral Auxiliary - Asymmetric Alkylation

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