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Synlett 1995; 1995(9): 907-908
DOI: 10.1055/s-1995-5149
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An Expedient Entry to Cephalosporin Derivatives with Cyclic Substituents at the 3-Position by [3+2] Cycloaddition Reactions

Han-Young Kang1 , Yong Seo Cho, Hun Yeong Koh, Moon Ho Chang2
  • 1Department of Chemistry, Chungbuk National University, Cheongju, Chungbuk 360-763, Korea
  • 2Division of Applied Science, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea
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Publication History

Publication Date:
31 December 2000 (online)

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Synthesis of cephalosporin derivatives with cyclic substituents at the 3-position was efficiently achieved by the intramolecular 1,3-dipolar cycloaddition reactions. It has been confirmed that 3-alkylidenecepham-4-carboxylic acids derivatives could be utilized as efficient intermediates for preparation of the desired cephalosporin derivatives. Efficiency of the synthetic route was shown using a nitrone and a nitrile oxide derivatives as dipole components.

Synthesis - β-Lactam - Cephalosporin derivatives - Cyclic substituents - Cycloaddition

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