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Synlett 1995; 1995(8): 839-840
DOI: 10.1055/s-1995-5096
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Facile Reduction of Carboxylic Acid Imidazolides to Primary Alcohols in the Presence of Water

Rajiv Sharma1 , George H. Voynov, Timo V. Ovaska2 , Victor E. Marquez
  • 1Laboratory of Medicinal Chemistry, DTP, DCT, NCI, National Institutes of Health, Building 37 Room 5C02, Bethesda, Maryland 20892, USA
  • 2Department of Chemistry, Connecticut College, New London, Connecticut 06320, USA
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Publication History

Publication Date:
31 December 2000 (online)

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A convenient protocol for selective reduction of carboxylic acid imidazolides to primary alcohols, which tolerates bromo, nitro, cyano, ester and amide functional groups, is disclosed.

Reduction - imidazolides - primary alcohols - sodium borohydride

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