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Synlett 1995; 1995(8): 815-816
DOI: 10.1055/s-1995-5094
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An Efficient Synthesis of Internal Guanidines

Soo Y. Ko* , Joanne Lerpiniere, A. Maria Christofi
  • *Sandoz Institute for Medical Research, 5 Gower Place, London WC1E 6BN, U.K.
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Publication Date:
31 December 2000 (online)

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An efficient synthetic method for internal guanidines has been developed, employing as the key step, a nucleophilic substitution of bis-BOC-protected terminal guanidines.

N,N’-disubstituted guanidines - bis-BOC-guanidines - alkylation

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