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Synlett 1995; 1995(6): 659-660
DOI: 10.1055/s-1995-5020
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The addition of N-lithiated amines to 1,1,1-trifluoromethylstyrene, a concise synthesis of 3-gem-difluoro-2-phenyl allylic amines

Jean-Pierre Bégué, Danièle Bonnet-Delpon, Michael H. Rock*
  • *BioCIS-CNRS, Centre d’Etudes Pharmaceutiques, Rue J.B. Clément, F-92296 Châtenay-Malabry, France, Fax 33 1 46 83 57 40
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Publication Date:
31 December 2000 (online)

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3-gem-Difluoro-2-phenyl allylic amines have been prepared in good to excellent yields by the treatment of 1,1,1-trifluoromethylstyrene with N-lithiated amines.

N-lithiated amines - 1,1,1-trifluoromethylstyrene - 3-gem-difluoro-2-phenyl allylic amines

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