Highly Stereocontrolled Addition of Methyltitanium Reagent to α-Phenylthioaldehyde

Tsuneo Sato; Junzo Otera

doi:10.1055/s-1995-4976

Synlett 1995; 1995(4): 351-352
DOI: 10.1055/s-1995-4976

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Highly Stereocontrolled Addition of Methyltitanium Reagent to α-Phenylthioaldehyde

Tsuneo Sato, Junzo Otera^*

^*Department of Applied Chemistry, Okayama University of Science, Ridai-cho, Okayama 700, Japan

Abstract

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Addition of MeTiCl₃ or its THF complex to α-phenylthioaldehydes occurs in a highly diastereoselective manner to give syn-β-phenylthioalcohols.

α-phenylthioaldehyde - methyltitanium trichloride - methyl Grignard reagent - methyllithium - diastereoselectivity

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