Synlett 1995; 1995(1): 74-76
DOI: 10.1055/s-1995-4864
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of 2-[2-(Diphenylphosphino)ferrocenyl]oxazoline Ligands

Christopher J. Richards* , Thanasis Damalidis, David E. Hibbs, Michael B. Hursthouse
  • *Department of Chemistry, University of Wales College of Cardiff, Cardiff, CF1 3TB, U.K.
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Dehydration of β-hydroxy amide 5, generated by condensation of (S)-(+)-valinol with ferrocenoyl chloride, gives (S)-2-ferrocenyl-4-(1-methylethyl)oxazoline 7. This is employed in the synthesis of (S)-2-[(S)-2-(diphenylphosphino)ferrocenyl]-4-(1-methylethyl)oxazoline 8 and the corresponding (S)-(R) diastereoisomer 9; a complementary pair of ligands for use in asymmetric catalysis.