Download PDF
Synthesis 1995; 1995(12): 1511-1516
DOI: 10.1055/s-1995-4146
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A General Approach to the Synthesis of Bisindolylmaleimides: Synthesis of Staurosporine Aglycone

Margaret M. Faul* , Kevin A. Sullivan, Leonard L. Winneroski
  • *Chemical Process Research & Development, Eli Lilly & Company, Indianapolis, Indiana 46285-4813, USA, Fax +1(317)2764507
Further Information

Publication History

Publication Date:
31 December 2000 (online)

 PDF Download  Permissions and Reprints All articles of this category
Preview

Bisindolylmaleimides are prepared in 65-95% yield by reaction of an indole Grignard with either 2,3-dichloro-N-methylmaleimide or 2,3-dichloromaleimide. A one-step synthesis of arcyriarubin A in 72% yield affords ready access to the staurosporine aglycone.

dihalomaleimides - indolyl-MgBr - bisindolylmaleimides - arcyriarubin A - staurosporine aglycone