A General Approach to the Synthesis of Bisindolylmaleimides: Synthesis of Staurosporine Aglycone
31 December 2000 (online)
Bisindolylmaleimides are prepared in 65-95% yield by reaction of an indole Grignard with either 2,3-dichloro-N-methylmaleimide or 2,3-dichloromaleimide. A one-step synthesis of arcyriarubin A in 72% yield affords ready access to the staurosporine aglycone.
dihalomaleimides - indolyl-MgBr - bisindolylmaleimides - arcyriarubin A - staurosporine aglycone