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Synthesis 1995; 1995(11): 1355-1356
DOI: 10.1055/s-1995-4129
short paper
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Improved Synthesis of a Selective COX-2 Inhibitor, 6-(2,4-Difluorophenoxy)-5-methanesulfonamidoindan-1-one (Flosulide)

Chung-Sing Li* , Chantal Soucy-Breau, Natalie Ouimet
  • *Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada Inc., P.O. Box 1005, Pointe-Claire-Dorval, Quebec, H9R 4P8, Canada, Fax +1(514)6950693
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Publication Date:
31 December 2000 (online)

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An improved synthesis of Flosulide (1), a selective COX-2 inhibitor, from the cheap and commercially available 4-chloro-3-nitrobenzaldehyde (2) by using an intramolecular Friedel-Crafts reaction of 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid (7) as the key step is reported.

COX-2 inhibitor - intramolecular Friedel-Crafts reaction - Flosulide