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Synthesis 1995; 1995(9): 1079-1080
DOI: 10.1055/s-1995-4076
short paper
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Synthesis of a Novel Water-Soluble Tetra[1-(O-ethylphosphatobutyl)]zinc Phthalocyanine

Ross W. Boyle, Johan E. van Lier*
  • *MRC Group in the Radiation Sciences, Faculty of Medicine, University of Sherbrooke, Sherbrooke (Québec) J1H 5N4, Canada, E-mail juanLier@courrier.usherb.ca
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Publikationsdatum:
31. Dezember 2000 (online)

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Tetra[1-(O-ethylphosphatobutyl)]zinc phthalocyanine tetrasodium salt 4 was synthesized from 4-nitro-1,2-dicyanobenzene in six steps. The potential of 4 as a sensitizer for photodynamic cancer therapy was demonstrated in a mouse tumor model.

The title compound (4) was synthesised in six steps from 4-iodo-1,2-dicyanobenzene