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Synthesis 1995; 1995(7): 810-814
DOI: 10.1055/s-1995-4015
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Synthesis of Orthogonally Protected L-Homocysteine and L-2-Amino-4-phosphonobutanoic Acid from L-Homoserine

Shrikumar A. Nair, Bongyong Lee, David G. Hangauer*
  • *Department of Medicinal Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA, Fax +1(716)6452393
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Publication History

Publication Date:
31 December 2000 (online)

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Convenient syntheses of N-tert-butoxycarbonyl-S-p-methoxybenzyl-L-homocysteine benzyl ester and benzyl L-4-dimethylphosphono-2-N-phthalimidobutanoate from commercially available L-homoserine are described along with their incorporation into dipeptides.

L-homoserine - L-homocysteine - L-2-amino-4-phosphonobutyrate - L-2-amino-4-bromobutyrate

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