Synthesis 1994; 1994(11): 1124-1126
DOI: 10.1055/s-1994-25650
short paper
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Novel and Efficient Synthesis of 6-Chloro-2-(substituted amino)benzoxazoles

József Kövér* , Tibor Tímár, József Tompa
  • *Department of Chemical Research I, Alkaloida Chemical Company Ltd., Tiszavasvári, H-4440, Hungary
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Publikationsdatum:
25. April 2002 (online)

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A novel and efficient synthesis of a number of 2-(substituted amino)benzoxazoles is described. 6-Chloro-2-phenoxybenzoxazole (3) reacts smoothly with a series of aliphatic primary amines 4a-j to give 6-chloro-2-(substituted amino)benzoxazoles 5a-j at room temperature in the presence of excess of amines.