A New and Easy Synthesis of Silylated Furanoid Glycals in One Step from Nucleosides

Erik Larsen; Per T. Jørgensen; Mamdouh A. Sofan; Erik B. Pedersen

doi:10.1055/s-1994-25633

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Synthesis 1994; 1994(10): 1037-1038
DOI: 10.1055/s-1994-25633

short paper

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A New and Easy Synthesis of Silylated Furanoid Glycals in One Step from Nucleosides

Erik Larsen^* , Per T. Jørgensen, Mamdouh A. Sofan, Erik B. Pedersen

^*Department of Chemistry, Odense University, DK-5230 Odense M, Denmark

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Publication Date:
27 September 2002 (online)

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Silylated furanoid glycals are synthesized in high yields by elimination of the nucleobase in thymidine (1a) and 5′-O- (tert-butyldiphenylsilyl)thymidine (1b) on treatment with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) in the presence of ammonium sulfate at reflux temperature for 2 hours.