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Synthesis 1994; 1994(8): 800-804
DOI: 10.1055/s-1994-25578
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Convenient Synthesis of Trichloromethyldihydroquinolines and -isoquinolines

Micheline Grignon-Dubois* , Faïza Diaba, Marie-Catherine Grellier-Marly
  • *Laboratoire de chimie organique et organométallique, Université Bordeaux I, 351, Cours de la Libération, F-33405 Talence-Cedex, France
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Publication Date:
17 September 2002 (online)

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The reaction of a series of N-alkylquinolinium and -isoquinolinium iodides towards sodium trichloroacetate in acetonitrile has been investigated under reflux or ultrasonication. In all cases, addition of trichloromethyl anion was observed, and trichloromethyldihydroquinoline or -isoquinoline derivatives were obtained in good yields. Depending on the activation process, addition occured at the 2- or the 4-position with quinolines and at the 1-position with isoquinolines.

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