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Synthesis 1994; 1994(8): 765-766
DOI: 10.1055/s-1994-25565
short paper
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Studies on Isocyanides and Related Compounds: A Novel Synthesis of Pyrroles via Ugi Reaction

Ricardo Bossio* , Stefano Marcaccini, Roberto Pepino
  • *CNR, Centro di Studio sulla Chimica e la Struttura dei Composti Eterociclici e loro Applicazioni, Dipartimento di Chimica Organica "Ugo Schiff", Università di Firenze, via Gino Capponi 9, I-50121 Firenze, Italy
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Publication Date:
17 September 2002 (online)

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A series of N-substituted 1,3-diaryl-4-cyano-2,5-dihydro-5-oxopyrrole-2-carboxamides 9 is obtained by reacting arylglyoxal anils 6 with isocyanides 3 and cyanoacetic acid (2). Compounds 9 react quickly with diazomethane to give N-substituted 1, 3-diaryl-4-cyano-5-methoxypyrrole-2-carboxamides 12.

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