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Synthesis 1994; 1994(5): 494-498
DOI: 10.1055/s-1994-25511
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Asymmetric Hydrogenation of 2-Benzylidenesuccinic Acid 4-[(4-BOC-amino)-1-piperidide] Monoamide: Key Step in a Process for Large Scale Preparation of a Renin Inhibitor

Heiner Jendralla*
  • *Hoechst AG, Allgemeine Pharma Forschung, Postfach 800320, 65926 Frankfurt/Main 80 Germany
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Publikationsdatum:
17. September 2002 (online)

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The N-terminal component 4 of an orally active renin inhibitor is prepared on kg-scale by asymmetric hydrogenation of the title compound 3. Enantioselectivities of several homogeneous homochiral rhodium(I)- and ruthenium(II)-diphosphine catalysts are compared.