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Diastereoselective Michael Addition of Nitromethane to Enoates Derived From (R)-Glyceraldehyde Acetonide
17 September 2002 (online)
The Michael addition of nitromethane to enoates derived from glyceraldehyde acetonide leads to syn-adducts 3 with high diastereoselectivity (de 76-90 %). The stereochemistry of the new stereogenic center was determined by transforming the Michael adduct 3b into lactone 6a.