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Synthesis 1994; 1994(4): 391-395
DOI: 10.1055/s-1994-25484
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General and Versatile Approach to the Synthesis of Optically Active 5- Alkylpiperazine-2-carboxylic Acids

Massimo Falorni* , Giampaolo Giacomelli, Michele Satta, Sergio Cossu
  • *Dipartimento di Chimica, Università di Sassari, Via Vienna 2, I-07100 Sassari, Italy
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Publikationsdatum:
17. September 2002 (online)

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General and convenient syntheses of optically active 5-alkylpiperazine-2-carboxylic acids are described. The methods are based on cyclization of L- or D-serine with α-amino acids and occur without loss of optical purity. The presented procedures are based on readily available starting materials and can be arranged for multigram quantities.