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Synthesis 1994; 1994(1): 23-24
DOI: 10.1055/s-1994-25395
short paper
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A Novel Synthetic Route to 1-Aminoalkylphosphinic Acids

Xian-Yun Jiao* , Christophe Verbruggen, Marianne Borloo, Willy Bollaert, Alex De Groot, Roger Dommisse, Achiel Haemers
  • *Department of Pharmaceutical Chemistry, University of Antwerp (UIA), Universiteitsplein, 1, B-2610 Antwerp, Belgium
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Publication History

Publication Date:
17 September 2002 (online)

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A "one-pot" synthesis of various 1-aminoalkylphosphinic acids is described. They were obtained in high yield by the deprotection of the corresponding bis(trimethylsilyl) N-tritylaminoalkylphosphites. The latter were prepared by addition of bis(trimethylsilyl) phosphonite to a Ntritylalkanimine.

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