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Synlett 1994; 1994(8): 584-586
DOI: 10.1055/s-1994-22934
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Synthesis of the Taxol Derivatives: Control of Atropisomerism

Takashi Nakamura* , Nobuaki Waizumi, Koichi Tsuruta, Yoshiaki Horiguchi, Isao Kuwajima
  • *Department of Chemistry, Tokyo Institute of Technology, Meguro, Tokyo 152, Japan
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Publication Date:
18 September 2002 (online)

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An efficient synthesis of taxol derivatives was accomplished by the Lewis acid mediated intramolecular coupling of the dienol silyl ether and the acetal, in which controlling the atropisomerism of the cyclization precursor is crucial.

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