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Synlett 1994; 1994(7): 507-508
DOI: 10.1055/s-1994-22906
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Synthesis of Trifluorolactic Acid from 1,2-Epoxy-3,3,3-Trifluoropropane. - One Pot Tandem Ring Opening-Oxidation Reaction of Epoxide -

Toshimasa Katagiri* , Fumihiro Obara, Sanae Toda, Keizo Furuhashi
  • *Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation, Niizo-Minami, Toda-shi, Saitama, 335, JAPAN
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Publication Date:
18 September 2002 (online)

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Optically active trifluorolactic acid (1????) was synthesized from optically active 1,2-epoxy-3,3,3-trifluoropropane (2????) by nitric acid oxidation. This nitric acid oxidation proceeded smoothly with a prior addition of a catalytic amount of copper metal.