Download PDF
Synlett 1994; 1994(6): 451-453
DOI: 10.1055/s-1994-22887
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Zirconocene-Mediated Synthesis of 3,4-Disubstituted Piperidines and Reduced Isoquinolines

Mark I. Kemp* , Richard J. Whitby, Steven J. Coote
  • *Department of Chemistry, The University, Southampton, SO9 5NH, England
Further Information

Publication History

Publication Date:
18 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

4-Aza-1,7-octa-dienes, -enynes, -ynenes and -diynes are converted to 3-aza-8-zirconabicyclo[4.3.0]non-anes,-6-enes,9-enes or 6,9-dienes when treated with 'ZrCp2' (where Cp = η5-C5H5). Protonolysis, iodinolysis, or carbonylation of these complexes affords 3,4-disubstituted piperidines. 1,3-Dienes formed from the coupling / protonolysis of 4-aza-1,7-octadiynes react with activated dienophiles to yield reduced isoquinolines.

      >