Download PDF
Synlett 1994; 1994(4): 295-296
DOI: 10.1055/s-1994-22835
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

An Asymmetric Synthesis of Muscarine, Suitable for the Elaboration of 5- Substituted Analogues

David W. Knight* , Duncan Shaw, Garry Fenton
  • *Chemistry Department, University Park, Nottingham, NG7 2RD, England
Further Information

Publication History

Publication Date:
22 March 2002 (online)

 PDF Download  Permissions and Reprints All articles of this category
Preview

A total synthesis of (-)-Muscarine 11 has been achieved, starting from (S)-malic acid 4, via the epoxy-ester 5, and proceeding by way of an unusual cyclisation of the homoallylic alcohol 7 which gives the hydroxy-tetrahydrofuran 8a highly stereoselectively.