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Synlett 1994; 1994(4): 241-242
DOI: 10.1055/s-1994-22810
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Synthesis of 2′-deoxy-2′-α-monofluoromethyl and trifluoromethyl Nucleosides

Chantal Schmit*
  • *Central Research Laboratories, Ciba-Geigy Ltd., CH-4002 Basel, Switzerland
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Publikationsdatum:
22. März 2002 (online)

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Coupling of 2′-deoxy-2′-α-monofluoromethyl and trifluoromethyl ribose derivatives with bissilylated thymine afforded a mixture of α- and β- nucleosides which were further transformed into their corresponding pure β-phosphoramidites.