PDF icon PDF herunterladen
Synthesis 1993; 1993(10): 961-963
DOI: 10.1055/s-1993-25979
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of 3,3-Difluoro-DL-alanine and 3,3-Difluoro-DL-alanine Precursors

Hugues d'Orchymont*
  • *Marion Merrell Dow Research Institute, Strasbourg Research Center, 16, rue d'Ankara, B. P. 067, F-67046 Strasbourg Cedex, France
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
29. April 2002 (online)

 als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik
Preview

The key intermediate to 3,3-difluoroalanine, 2,2-difluoro-1-ethylthioethylamine hydrobromide (2), was prepared by the Steglich and Weygand procedure. Its conversion to N-benzyloxycarbonyl-2,2-difluoro-1-ethenylethylamine (5) followed by oxidation and subsequent deprotection of the amine afforded the 3,3-difluoroalanine.