Download PDF
Synthesis 1993; 1993(9): 867-869
DOI: 10.1055/s-1993-25958
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A New and Convenient Method for the Preparation of 2-Substituted Quinazolines

Jean Jacques Vanden Eynde* , Jérôme Godin, Annie Mayence, André Maquestiau, Ernst Anders
  • *University of Mons-Hainaut, Organic Chemistry Laboratory, Place du Parc 20, B-7000 Mons, Belgium
Further Information

Publication History

Publication Date:
29 April 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Aldehydes, converted in situ into N-(1-chloroalkyl)pyridinium chlorides using thionyl chloride and pyridine, react with 2-aminobenzyl-amine, under mild conditions, to yield 1,2,3, 4-tetrahydroquinazolines. The latter can be aromatized readily by treatment with 2,3-dichloro-5,6-dicyanobenzoquinone or tetrachloro-1,4-benzoquinone in benzene.

      >