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Synthesis 1993; 1993(6): 573-574
DOI: 10.1055/s-1993-25907
short paper
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Oxidative Cleavage of Aryl or Alkyl tert-Butyl Sulfides with Dimethyl Sulfoxide/Hydrobromic Acid to Form Symmetrical Aryl or Alkyl Disulfides

Daniel A. Dickman* , Sanjay Chemburkar, Donald B. Konopacki, E. Michael Elisseou
  • *Process Research, Pharmaceutical Products Division, Abbott Laboratories, One Abbott Park Road, Abbott Park, Illinois 60064, USA
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Publication Date:
17 September 2002 (online)

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The use of dimethyl sulfoxide and hydrobromic acid as a reagent to oxidatively cleave (tert-butylthio)benzaldehydes, aryl or alkyl tert-butyl sulfides to their corresponding symmetrical disulfides is discussed. A brief mechanistic rationale is given based upon several control experiments.

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