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Synlett 1993; 1993(7): 529-533
DOI: 10.1055/s-1993-22518
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Cobalt Mediated Propargylation of Indoles

Klaus-Dieter Roth*
  • *Institut für Organische Chemie, Universität Erlangen, Henkestraße 42, D-8520 Erlangen, Germany
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Publikationsdatum:
19. März 2002 (online)

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A thorough investigation of the reactions of dicobalthexacarbonyl stabilized propargyl cations 2 with differently substituted indoles 1 is described, leading to a general reaction scheme for this type of propargylations. The resulting products 3,5,7 and 9 (the latter arising from a tandem electrophilic/nucleophilic addition) and the corresponding demetalated compounds 4,6,8 and 10 should prove to be versatile building blocks for the synthesis of polycyclic indole derivatives.