Synlett 1993; 1993(7): 509-510
DOI: 10.1055/s-1993-22510
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The Preparation of Functionalised Aryl Phosphines from Aryl Fluorides by Nucleophilic Aromatic Substitution with Potassium Diphenylphosphide

Steven J. Coote* , Graham J. Dawson, Christopher G. Frost, Jonathan M. J. Williams
  • *Glaxo Group Research Ltd, Ware, Herts, SG12 0DP, England
Further Information

Publication History

Publication Date:
19 March 2002 (online)

The reaction of o-substituted aryl fluorides with potassium diphenylphosphide affords the corresponding o-substituted aryl phosphines by nucleophilic aromatic substitution in 72-96% yield. The products have wide application as ligands and ligand precursors.

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