Download PDF
Synthesis 1992; 1992(12): 1219-1220
DOI: 10.1055/s-1992-26341
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A New Method for Converting Nitriles into Primary Thioamides by Sodium Trimethylsilanethiolate

Pen-Yuan Lin* , Wei-Shan Ku, Min-Jen Shiao
  • *Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China
Further Information

Publication History

Publication Date:
29 April 2002 (online)

 PDF Download  Permissions and Reprints All articles of this category

A new method was developed for converting nitriles into primary thioamides. Treatment of various nitriles 1 with 1.5-2.5 equivalents of sodium trimethylsilyl sulfide (sodium trimethylsilanethiolate) in 1,3-dimethyl-2-imidazolidinone at 20-35°C for 4-30 hours gave the corresponding thioamides 2 in 27-80 % yield.