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Synthesis 1992; 1992(10): 951-953
DOI: 10.1055/s-1992-26275
short paper
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Synthesis and Application of (3R,4R)-3,4-Bis(diphenylphosphino)tetrahydrofuran as Ligand for Asymmetric Hydrogenation of Acrylic Acids

Andreas Terfort*
  • *Institut für Organische Chemie, Universität Göttingen, Tammannstraße 2, D-3400 Göttingen, Germany
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Publikationsdatum:
17. September 2002 (online)

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A new, chiral bisphosphine, (3R,4R)-3, 4-bis(diphenylphosphino)tetrahydrofuran (4), is synthesized in three steps from (R,R)-tartaric acid esters. With rhodium(I) complexes of 4enantiomeric excesses of 54 to 97% are obtained on catalytic hydrogenation of 2-(acetylamino)acrylic acid, 2-(acetylamino)cinnamic acids and itaconic acid. The applied substrate/catalyst ratios were between 250: 1 and 11000:1.