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Synlett 1992; 1992(4): 335-336
DOI: 10.1055/s-1992-22005
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A Mild and Practical Method for Removal of the Dithio Protecting Group Using Visible Light

Gary A. Epling* , Qingxi Wang
  • *Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA
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Publication History

Publication Date:
08 March 2002 (online)

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Dithianes and dithiolanes were cleaved in excellent yields to aldehydes or ketones in a deprotection procedure using visible light. A neutral solution of a dithio compound in acetonitrile/water was illuminated under nitrogen using an ordinary tungsten spot light. A dye-sensitized photocleavage of the dithio compound led to near-quantitative formation of the deprotected aldehyde or ketone.

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