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Synlett 1992; 1992(4): 327-328
DOI: 10.1055/s-1992-22002
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A Convenient Method for the Synthesis of C-5 Substituted 1-Tosylpyrazoles

Kevin I. Booker-Milburn*
  • *Department of Chemistry and Applied Chemistry, University of Salford, Salford M5 4WT, England
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Publication History

Publication Date:
08 March 2002 (online)

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Treatment of N-tosylpyrazole (1) with tert-butyllithium at -78 °C in tetrahydrofuran and alkylation of the resulting organolithium with a variety of electrophiles, gave rise to a number of C-5 substituted 1-tosylpyrazoles 3 in good to excellent yield.

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