Synlett 1992; 1992(12): 977-979
DOI: 10.1055/s-1992-21552
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Reformatsky Reaction of Ethyl 4-Chloro-4,4-difluorocrotonate. Preparation of α-Substituted 4,4-Difluoro-3-butenoates

Takashi Tsukamoto* , Tomoya Kitazume
  • *Department of Bioengineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 227, Japan
Further Information

Publication History

Publication Date:
08 March 2002 (online)

Reformatsky reagent derived from ethyl 4-chloro-4, 4-difluorocrotonate was found to react with carbonyl compounds in the α-mode by using Zn-Cu couple to afford α-substituted 4,4-difluoro-3-butenoates.

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