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Synlett 1992; 1992(10): 840-842
DOI: 10.1055/s-1992-21512
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Total Synthesis of 3,4-Dihydromilbemycin G: Synthesis of the 'Lower Hemisphere' of α-Milbemycins and Avermectins

Simon Bailey* , Sufia Karim, Eric J. Thomas
  • *Department of Chemistry, University of Manchester, Manchester, M13 9PL, England
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Publication Date:
08 March 2002 (online)

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Closure of the tetrahydrofuran ring via an intramolecular SN2 reaction is the last step in a convergent synthesis of 3,4-dihydromilbemycin G 13. The hydroxybutenolide 31 has been prepared and converted into the lactone 33.