Synlett 1992; 1992(10): 827-829
DOI: 10.1055/s-1992-21506
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Carboxalkylation of Enolates with Menthyl Chloroformate. Diastereoselective Formation of Quaternary Carbon Centers

Werner Trypke* , Alois Steigel, Manfred Braun
  • *Institut für Organische Chemie und Makromolekulare Chemie, Universität Düsseldorf, Universitätsstr. 1, D-4000 Düsseldorf 1, Germany
Further Information

Publication History

Publication Date:
08 March 2002 (online)

Diastereomeric rations of 90 : 10 to > 95 : 5 are reached when carboxylic acid, ketone, and ester-derived enolates 2, 7a/7b, 10, and 13 are allowed to react with (-)-menthyl chloroformate 1 to deliver nonracemic compounds which contain stereogenic quaternary carbon centers.

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