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Synlett 1992; 1992(10): 813-816
DOI: 10.1055/s-1992-21502
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Enantioselective Transesterifications Using Immobilized, Recombinant Candida antarctica Lipase B: Resolution of 2-Iodo-2-cycloalken-1-ols

Carl R. Johnson* , Hiroshi Sakaguchi
  • *Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA
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Publication Date:
08 March 2002 (online)

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Five- to seven-membered 2-iodo-2-cycloalken-1-ols were resolved by enantioselective transesterifications with isopropenyl acetate in hexane catalyzed by Candida antarctica B lipase; product (R)-acetates and recovered (S)-alcohols has ee's >95%. Related studies involving 2-bromo-2-cyclohexen-1-ol, hydrolyses of 2-halo-2-cycloalkenyl acetates and use of Pseudomonas cepacia lipase are described.

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