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Synlett 1992; 1992(10): 811-813
DOI: 10.1055/s-1992-21501
DOI: 10.1055/s-1992-21501
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© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved.
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data processing and storage.Preparation of Seven-Membered Cyclic Ethers Containing Halogenated Side Chains by Acetal-Alkene Cyclizations
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Publikationsdatum:
08. März 2002 (online)

Lewis acid-promoted cyclizations of β-chloro- (or β-bromo-) acetals prepared from vinyl ethers, 4-(trimethylsilyl)-4-penten-1-ols and Cl2 (or Br2) afford 2,3,6,7-tetrahydrooxepins containing 1-chloroalkyl (or 1-bromoalkyl) side chains at carbon 2. The chloride-containing cis-2,7-disubstituted-Δ4-oxepene ring system of the marine lipid isolaurepinnacin can be efficiently assembled in this way.