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Synlett 1992; 1992(9): 709-710
DOI: 10.1055/s-1992-21462
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A Short Synthesis of the Glycine Antagonist (3R,4R)-3-Amino-1-hydroxy-4-methyl-pyrrolidin-2-one (L-687,414)

M. Jonathan Fray* , David J. Bull, Keith James
  • *Pfizer Central Research, Sandwich, Kent CT13 9NJ, England
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Publication Date:
08 March 2002 (online)

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A new, short synthesis of the glycine antagonist 3R,4R)-3-amino-1-hydroxy-4-methylpyrrolidin-2-one (L-687,414) (1) is described, which proceeds in six steps (14% overall yield), starting from commercially available (S)-β-methyl-γ-butyrolactone (4).

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