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Metal Salt-Promoted Alcoholysis of 1,2-Epoxides
08 March 2002 (online)
A simple, efficient, stereoselective, and regioselective method for the synthesis of ß-alkoxy alcohols by the direct opening of 1,2-epoxides with alcohols (primary, secondary, and tertiary) in a nonprotic solvent or with the alcohol itself as the solvent, in the presence of a metal salt, is described. This new method appears to be competitive with and/or alternative to the other methods previously reported.