Synlett 1992; 1992(8): 663-664
DOI: 10.1055/s-1992-21450
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Ring-Opening Reactions of Epoxides with Trimethylsilyl Cyanide Catalyzed by Titanium Alkoxide-Schiff Base Complexes

Masahiko Hayashi* , Mayumi Tamura, Nobuki Oguni
  • *Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi City, Yamaguchi 753, Japan
Further Information

Publication History

Publication Date:
08 March 2002 (online)

The addition of Schiff base 4 [6-tert-butyl-2-(2-hydroxyethyliminomethyl)phenol] possessing a tert-butyl group accelerated the rate of ring-opening reactions of epoxides with trimethylsilyl cyanide catalyzed by titanium(IV) isopropoxide to afford the corresponding ß-trimethylsiloxy nitriles in a stereo- and regioselective manner.