Subscribe to RSS
An Improved Procedure for N-Formylation of Secondary Amines Using Chlorotrimethylsilane-Imidazole-N,N-Dimethylformamide
08 March 2002 (online)
An improved method for the N-formylation of secondary amines using chlorotrimethylsilane and imidazole in N,N-dimethylformamide is described. The reaction conditions are tolerant of ester functional groups, and an amine hydrochloride may be N-formylated using a slight modification of the procedure.