Synlett 1992; 1992(8): 659-660
DOI: 10.1055/s-1992-21448
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

An Improved Procedure for N-Formylation of Secondary Amines Using Chlorotrimethylsilane-Imidazole-N,N-Dimethylformamide

Malcolm B. Berry* , Julian Blagg, Donald Craig, Michael C. Willis
  • *Department of Chemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, England
Further Information

Publication History

Publication Date:
08 March 2002 (online)

An improved method for the N-formylation of secondary amines using chlorotrimethylsilane and imidazole in N,N-dimethylformamide is described. The reaction conditions are tolerant of ester functional groups, and an amine hydrochloride may be N-formylated using a slight modification of the procedure.