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Synlett 1992; 1992(6): 503-504
DOI: 10.1055/s-1992-21394
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Studies on α,β-Unsaturated 12-Membered-Ring Lactones: A Synthesis of (±)-Dihydrorecifeiolide

Leena Kaisalo* , Tapio Hase
  • *University of Helsinki, Department of Chemistry, Vuorikatu 20, Helsinki 10, Finland
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Publication Date:
08 March 2002 (online)

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An expedient route to (±)-dihydrorecifeiolide [12-methyloxacyclododecan-2-one (1)] and the related Z and E α,β-unsaturated 12-membered-ring lactones 2 and 3 is reported. Allylic oxidation of 2 and 3 at C-5, required for access to the patulolides, is problematic probably for conformational reasons.