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Synlett 1992; 1992(5): 439-441
DOI: 10.1055/s-1992-21373
DOI: 10.1055/s-1992-21373
letter
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Optically Active ß-Hydroxy Sulfoximine/Nickel Complexes as Catalysts for the Enantioselective Conjugate Addition of Diethylzinc to Chalcones
Further Information
Publication History
Publication Date:
08 March 2002 (online)
The conjugate addition of diethylzinc to chalcones 1a-d is Catalyzed by a combination of nickel acetylacetonate and ß-hydroxy sulfoximines 4-22. The ligand structure was optimized and an enantiomeric excess of up to 72% was achieved using (S,S)-N-ethyl-S-[(1-hydroxycyclopentyl) methyl]-S-phenylsulfoximine (6) as the chiral ligand.